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Mechanistically, PA reduces the expression of GPX4 and heat shock factor 1 and regulates the transcription of genes related to iron metabolism (such as FTH, TFR1, and SLC40A1), causing iron homeostasis imbalance, while GPX4 overexpression reverses PA-induced ferroptosis in cardiomyocytes

Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer

Zinc was described as having insulin-mimetic effects, so zinc supplements may be appropriate for people with diabetes

Malondialdehyde (MDA) and inflammatory cytokines concentration have been reduced after melatonin treatment in critical situations such as asphyxia, sepsis, and surgery [160-162]