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OTA detoxification using nanoparticles Activated carbon and graphene oxide are examples of high-surface area nanoparticles that may efficiently absorb OTA from contaminated materials, lowering its bioavailability [163], [183]

In fact, there are several types that have been developed to bypass this limitation

It has been suggested that frataxin is involved in the synthesis of iron-sulfur clusters, metabolism of heme, regulation of oxidative phosphorylation and mitochondrial bioenergetics amongst others ( FXN gene and its protein frataxin, as observed in FRDA patients, has been associated with mitochondrial iron overload, reduced ATP production, oxidative stress, downregulation of antioxidant response element (ARE) -regulated genes and consequential cell death of sensory neurons in the dorsal root ganglia (DRG) and dentate nucleus ( 2 Clinicopathologic characteristics of FRDA Based on the onset of the disease, the disease can be classified into three categories, namely the classical FRDA (when the symptoms are present between the ages of 10 and 16 years), late onset FRDA (LOFA) (when the symptoms are present after the age of 25), and very late onset FRDA (VLOFA) (where the symptoms are present after the age of 40)

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