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In addition to the leak and pore pathways, there is also the unrestricted (or apoptotic) pathway, where severe damage to the gut mucosa results in death of epithelial cells and permits unrestricted paracellular transport of large molecules and bacteria

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moreover, infection can cause astrocyte instability at the BBB and promote displacement of the AQP4 channels [76]

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Signalling to contractile proteins by muscarinic and purinergic pathways in neurally stimulated bladder smooth muscle

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