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A similarly high incidence of OS was reported in a recent clinical trial, with 83.8% (124 of 148 cases) of idiopathic infertile men having positive seminal oxidation-reduction potential (ORP), a measure of ROS-antioxidant discrepancy [unpublished data]

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Drug stimulation Drug concentrations were selected in relation to previously determined clinical human maximum plasma exposure (C max ) values of trovafloxacin and levofloxacin 25,27,77 , which are consistent with values from pharmacokinetic studies of single oral drug doses 78,79,80,81