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Advanced glycation end-products and insulin signaling in granulosa cells

5 Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Correspondence: Phisit Khemawoot, Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Tel/Fax +66 28395161, Email [email protected] Background: Our previous studies in vitro and in vivo have shown anti-severe acute respiratory syndrome coronavirus 2 activity of fingerroot extract ( Boesenbergia rotunda ) and its phytochemical panduratin A

They are supplied by increased activity of the PPP and glutaminolysis, which is largely mediated by high levels of HIF1 and mTOR [278, 280,281,282,283,284]

Alternatively, lipid peroxidation-mediated reduction in membrane fluidity or structural changes (e.g., reduced membrane thickness) may disrupt the function of the plasma membrane as a selective barrier