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It consists of a 31-amino acid peptide backbone with several structural modifications designed to extend its biological half-life, including a C-18 fatty acid chain attached via a linker to a lysine residue

To this end, siENPP2 was transfected into A375SM cells to knock-down ENPP2, and the knock-down efficiency was confirmed via RT-qPCR, western blot and ELISA

Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion may not be useful due to high protein binding