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Nevertheless, its clinical application is substantially hindered by poor bioavailability, which stems from low aqueous solubility, inefficient intestinal absorption, and rapid metabolism and systemic elimination

Among the genes that were most significantly upregulated by AGXT overexpression were members of the cytochrome P450 CYP2 family such as Cyp2c37 , Cyp2c50 , Cyp2c54 and Cyp2e1 that regulate FAO and polyunsaturated fatty acid (PUFA) metabolism 37,38 and Cd163 , a known marker of anti-inflammatory macrophages 39

10.2217/epi.11.71 56 HarlaarN.BryanA