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As the effective dose is near to LD 50 , therefore it has shown to cause neurotoxic effects

doi: 10.1016/S0006-3223(03)00469-4 46 KaradagN.ShadrinA

Analysis of the Relationship Between Hemorheologic Parameters, Aluminum, Manganese, and Selenium in Smokers

Annu Rev Pharmacol Toxicol 45 : 5188