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10.3390/molecules26113329 9 CifuentesJ.Cifuentes-AlmanzaS.PuentesP

Key findings include: Upregulation of Shh pathway components in ischemic brain regions Enhanced neural stem cell proliferation and differentiation Improved angiogenesis supporting tissue repair Modulation of blood-brain barrier integrity The Shh pathway activation appears particularly relevant in stroke recovery models, where enhanced neurogenesis and vascular support correlate with functional improvements

Here, we combine our APAP model [10] with the one-carbon and glutathione model described in Methods