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doi:10.1177/0960327113506723 Joshi EM, Heasley BH, Macdonald TL (2009) 2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: implications for toxicity associated with zileuton

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Of special interest in this context are lipid peroxidation products, in particular 4-hydroxynonenal (HNE), which has been shown to both induce DNA damage [96] but also to be involved in the regulation of cell proliferation and growth as well as necrotic or apoptotic cell death by its marked ability to modulate several major pathways of cell signaling and, consequently, gene expression (for review see [97])

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