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Fernndez-Trujillo, A

Anecdotal nootropic and biohacker protocols combine the two peptides to layer the cognitive enhancement of Semax with the anxiolytic profile of Selank

Some researchers combine it with KPV to address both the immune overreaction and the tissue damage simultaneously

In addition, IBD patients demonstrate increased intestinal paracellular permeability, which reflects decreased epithelial barrier function in IBD.59 Clinical studies show decreased expression and redistribution of barrierforming proteins, including occludin, claudin-3, -5, -8, and JAM-A, and increased expression of pore-forming claudin-2 in CD patients.60,61 In UC patients, decreased expression and redistribution of occludin, claudin-1, -4, and JAM-A, and increased caludin-2 expression are observed.61 In addition, MLCK expression and MLC phosphorylation are also observed in the intestines of both UC and CD patients, indicating that cytoskeletal dysregulation is involved in the increased intestinal permeability of IBD patients.62 Clinical studies show that the levels of inflammatory cytokines, including TNF-,63 IFN-,39 IL-1,44 IL-6,64 and IL-1754 are elevated in the intestines of IBD patients