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Studies using a recombinant HSV-1 expressing IL-2 reported the presence of auto-reactive T cells in the brain and CNS demyelination, supporting the hypothesis that both, virus and IL-2 play roles in the demyelination process and that HSV-1 could be important at initiating the destruction of myelin in the presence of elevated levels of IL-2 (Osorio et al., 2005

There are numerous potential hammerhead ribozyme cleavage sites within each nucleotide sequence disclosed in the sequence listing

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