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In addition, previous studies have shown that MG and D-lactic acid levels are significantly increased in aristolochic acid-induced and STZ-injected mouse models of kidney injury ( in vivo validation through targeted interventions It has been shown that MG is derived mainly from glycolysis ( 13 C-pyruvate tracing will delineate its fate in MG-rich microenvironments
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Impaired NO signaling can disrupt cardiac function by lowering cGMP levels, which are essential for smooth muscle relaxation and proper heart filling
