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However, targeting inflammatory cytokines in cachexia fails to properly counteracts the syndrome, suggesting that systemic inflammation might be crucial in the induction of cachexia but not essential for its maintenance (Olson, et al., 2021b)
The success of G12C inhibitors fundamentally changed the perception of KRAS from an "undruggable" target to a clinically actionable oncogenic driver and established the foundation for subsequent KRAS-targeted drug development
Cell Transpl
