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The lead candidate 37 (HFI-419) exhibits brain exposure following intravenous administration in rats but was found to be rapidly degraded to the corresponding deacetylated and less active IRAP inhibitor (Mountford et al., 2014)

PLoS ONE 6(11):e27798

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We next examined immunovascular interactions in PBMCs isolated from patients with COVID-19 and found increased adhesion of PBMCs to human brain endothelial cells in the cohort with long COVID compared to unaffected individuals, which was heightened in the presence of TNF and only modestly affected by blocking antibodies against ICAM-1 and VCAM-1 (Extended Data Fig