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Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study

Age-related reduction of mitochondrial function is accompanied by a decline in the mitochondrial capacity for ATP production by oxidative phosphorylation [62], a reduction in the NAD + pool [63] by consuming processes (PARP, CD38, and SIRT1) [64], and further an increase in ROS generation by an inefficient electron transport chain (ETC) [26]

[DOI] [PMC free article] [PubMed] [Google Scholar] 291.Ma Z, Choudhury JR, Wright MW, Day CS, Saluta G, Kucera GL, Bierbach U
