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The main proteins responsible are sulfhydryl oxidases, which often incorporate iron, copper, or flavin binding domains to participate in oxidation-reduction reactions (Kodali and Thorpe, 2010)

Clinical and animal studies have demonstrated the efficacy of benfotiamine in the treatment of diabetes-related neuropathy, kidney disease, peripheral vascular disease, and retinopathy (Stirban 2006

We summarize the key molecular mechanisms that drive the pathogenesis of diabetes and its associated complications in Fig