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Shaking creates shearing forces and foam, which can denature the peptide chains, essentially ripping the complex folded structure apart

J Eur Ceram Soc 38(3):871876 Malhotra A, Habibovic P (2016) Calcium phosphates and angiogenesis: implications and advances for bone regeneration

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This overwhelms the iron homoeostasis and iron clearance system, finally leading to an iron-overloaded environment in peritoneal fluid and ectopic lesions of endometriosis [88]