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Nrf2 is a key component of this control system and recognizes the antioxidant response element (ARE) found in the promoter regions of many genes that encode antioxidants and detoxification enzymes such as heme oxygenase 1 (HO-1), NAD(P)H dehydrogenase quinone 1, SOD1, glutathione peroxidase 1 (GPx1), and CAT (Itoh et al., 1997)

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