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Studies have suggested that MMPs degrade the vascular basement membrane components, resulting in disruption of the BBB (Jin et al., 2019), and that excess iron accumulation will initiate the Fenton reaction to generate ROS (Xu et al., 2020)

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This article reviews the evidence that NRF2 activation declines with ageing

A review by Done and Traustadttir [23] highlights that both regular and acute exercise are crucial for activating the Nrf2 pathway, a key regulator of the bodys antioxidant defences