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Is the depletion of NADPH by the inhibition of the oxidative PPP elicits compensatory alternative mechanisms that generate NADPH 59,60

Correction: From bench to bedside: ROS-Responsive nanocarriers in cancer therapy

Summary The prevailing view on the role of glutathione in protein disulphidebond formation is that this tripeptide acts as a net reductant in the ER, either by maintaining ER oxidoreductases in a reduced state or by directly reducing nonnative disulphide bonds in substrate folding proteins

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