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ASCO 20:303, 2001

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19 , e12726 (2017)

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Subsequently, N-acetyl serotonin is ultimately converted into melatonin by the enzyme known as N-acylserotonin methyltransferase (ASMT) Tryptamine and 5-hydroxytryptophan are metabolized into serotonin through the activity of tryptamine 5-hydroxylase (T5H) and tryptophane decarboxylase (TDC) enzymes, respectively (175, 178, 179)

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Ethics declarations Ethical approval Animal studies were conducted in accordance with the ethical guidelines for investigations in laboratory animals and were approved by the Ethical Committee of Faculty of Pharmacy, Mansoura University, Egypt, which is in accordance with the Principles of Laboratory Animal Care (NIH publication no

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