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thus, GCL is considered the rate-limiting enzyme [6]
MKK3/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells
10.1002/ange.202403963
However, preliminary results suggest that high doses of NAC, still within therapeutic margins, do not limit but increase oxidative stress in the cochlea after treatment with ototoxic drugs, which share oxidative stress-related pathogenic pathways with NIHL
