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Evidence Boundary Most studied route in the Phase 2 program, but the OPTIONS trial missed its primary weight-loss endpoint and development was terminated in 2007

The following databases were searched: Ovid MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, Ovid Embase, Wiley Cochrane, EBSCO Cumulative Index to Nursing & Allied Health Literature (CINAHL), and Centre for Reviews and Dissemination/International Agency for Health Technology Assessment

Since NNMT expression is directly determined by the NNMT gene, in our previous works, nineteen SNPs in the NNMT DNA sequence were selected as tagSNPs using Haploview software (Haploview 4.2) to observe the association between NNMT gene polymorphisms and obesity [29] and hyperlipidemia [30]

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