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Furthermore, non-canonical routes to acetyl-CoA production outside of mitochondria have also been proposed, with several studies reporting a moonlighting function of the pyruvate dehydrogenase complex (PDC), which can translocate to the nucleus under specific conditions to generate a local source of acetyl-CoA from pyruvate for histone acetylation 1518

Find out what research shows in the What to Consider When Buying section of our Acetyl-L-Carnitine Supplements Review

doi: 10.1093/nar/gkae973 Summary Keywords atheroscelrosis, cholesterol metabolism, acetyl-L-carnitine (ALC), SREBP2, HMGCR Citation Xing J, Du Z, Li F, Wang Y, Zhang Z, Gao X, Han L, Sun X, Sun H, Du Y, Hu C, Yu H and Qin Y (2024) Acetyl-L-carnitine ameliorates atherosclerosis in LDLR / mice by modulating cholesterol metabolism through SREBP2-dependent cholesterol biosynthesis