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When assessed using Relational database of Metabolomic Pathways (RaMP-DB) that has 3694 metabolite and lipid pathways integrated from KEGG, HMDB, Reactome and WikiPathways, the significant pathways were Oligodendrocyte specification and differentiation leading to myelin components for CNS, Immunoregulatory interactions between lymphoid and non-lymphoid cells, Kennedy pathway from sphingolipids, MTHFR deficiency, Sphingolipid pathway and Glycerolipids and glycerophospholipids

K.Johnson-BeeboutS

Under normal conditions, GSK3 is maintained in an inactive state due to its inhibition by AKT-mediated phosphorylation at its N-terminal pseudosubstrate domain

1 A , Extended Data Fig