oral glutathione low bioavailability system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis bioavailability_the_first_pass_effect [TUSOM | Pharmwiki]

However, two small clinical trials showed no significant effect compared to controls

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( In the herbal medicines examined, AC591 and Guilongtongluofang were associated with statistically significant reduction in the risk of OIPN ( Astragalus membranaceus , the main component in both AC591 and Guilongtongluofang ( The strengths of this study include the comprehensive coverage of interventions studied between 2005 and 2020, the strict selection criteria for only prospective RCTs where the patients were nave to neurotoxic chemotherapy, the specificity for chronic OIPN which is distinct from peripheral neuropathy associated with other chemotherapy agents such as cisplatin or paclitaxel, and the holistic rating of interventions using a combination of RR, GRADE score, and risk of bias assessment