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Cancer cachexia: more than skeletal muscle wasting

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Elevated TMAO downregulates hippocampal antioxidant enzyme MsrA, contributing to neuroinflammation and cognitive decline post-surgery in aged rats (143)

Once the balance is aberrant, disorders in the composition and structure of the intestinal microbiota transform the intestinal microecological environment from healthy state to disease state, subsequently resulting in the pathogenesis of various common metabolic disorders including obesity, type 2 diabetes, non-alcoholic liver disease, cardio-metabolic diseases, and malnutrition (22, 23)