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Even though the immune system responds towards inflammatory stimuli through ROS, increased ROS levels can damage DNA, proteins, and lipids, and result in activating various signaling pathways (such as NF-B and mitogen-activated protein kinase (MAPK)), stimulating T helper cells 1 (Th1) and Th17 cells, and promoting the release of inflammatory cytokines (Plenkowska et al., 2020), which can contribute to the development and exacerbation of the psoriatic inflammation

Semaglutide (weekly) is the most widely used

Long-term use of metformin, proton pump inhibitors or H2 blockers , which can reduce B12 absorption over years

Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice