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C57BL/6J mice, C57 Black 6 Jackson Laboratory mice

Importantly, drug-resistant tumor are more sensitive to lipid peroxidation, which undoubtedly makes, the combination of System X c /GSH/GPX4 axis-based ferroptosis inducers with chemotherapeutic agents may become a new strategy for the treatment of drug-resistant solid tumors (Viswanathan et al., 2017)