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Ferroptosis inhibitors that enhance antioxidant defenses and block the Fenton reaction have shown efficacy in animal models by improving neurological function and reducing disease severity

The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48

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