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Description
Maintenance doses are typically given monthly, but some people may require injections every few months

Begin conservatively and adjust only under appropriate guidance

Dosing every 23 weeks is appropriate only during maintenance phases after initial weight loss has plateaued

Diagnostic Criteria (Adapted from consensus guidelines): Chronic multisystem symptoms consistent with mast cell activation Evidence of elevated mast cell mediators (during flare or baseline), such as: Serum tryptase Plasma histamine Chromogranin A Urinary N-methylhistamine Urinary prostaglandin D2 or F2 Improvement with medications that block mast cell activity (e.g., antihistamines, cromolyn sodium) Testing is most accurate when done during or soon after a flare , and samples often need to be chilled and analyzed at specialized labs
