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Relationship between copper and immunity: the potential role of copper in tumor immunity

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Nat Rev Immunol 8:411420 Avissar NE, Sax HC, Toia L (2008) In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3 K, and Rho-dependent

In a previous study, high concentrations of iron and cadmium increased oxidative stress in the seminal plasma and sperm homogenate of the infertile group, decreased the content of antioxidants, and thus had a strong toxic effect on spermatogenesis by producing excessive oxidants and inducing apoptosis (14)