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reported that AS-IV can enhance the If current density in I/R-injured sinoatrial node cells, shorten APD at 20% and 50% repolarization in SAN cells, and upregulate HCN4 expression, thus helping maintain cell volume and cytoskeletal integrity in SAN cells, with potential therapeutic effects for sick sinus syndrome (Liu et al., 2018)

The combination of curcumin with the PI3K-specific inhibitor LY294002 has shown a beneficial effect by increasing the inhibition of Bcl-2 protein [172]

Researchers examine how the combination affects collagen deposition, angiogenesis, inflammatory resolution, and functional recovery in experimental systems of tendon/ligament injury, muscle damage, ulcer models, and other tissue repair scenarios

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