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However, the use of modified nanomedicines engineered with different ligands that can be recognized by receptors expressed in the BBB offers a favorable alternative for this purpose

[2] After the promising results from the 12-week trial, a more extended 24-week trial was conducted with a larger group of 536 subjects

Cancer Res 79:59205929

For the parallel review of TB-500 specifically, see our TB-500 FDA approval status 2026 breakdown