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This review explores the role of SAMe in cancer establishment and development, as well as its potential as a biomarker and therapeutic target.Overview of S-Adenosylmethionine Synthesis Focusing on mammals, although being synthesized in all cells, liver is the organ where most SAMe is produced, accounting for about 85% of transmethylation reactions and 50% of methionine metabolism [4,5]

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10.1016/j.rmed.2012.10.011 142

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For example, in a study conducted by Constantin and onea (2018), in which NAC was used to treat bovine endometritis, the clinical cure rate in the NAC group was 77.2% versus 43.4% in the non-NAC group [102]

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