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Compared with controls, the experimental group showed a small, nonsignificant increase in leg muscle mass (+0.28 kg), but significant gains in appendicular muscle mass (+0.36 kg) and total lean mass (+0.92 kg)

Then, denaturation was performed for further circularization of the formed single-stranded DNA using the commercial MGIEasy Dual Barcode Circularization Module kit (MGI, China)

We also observed a positive correlation between KG and l-carnitine/acetylcarnitine using cell-line data from DepMap (Extended Data Fig