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Results are presented using descriptive statistics, including the number of observations, geometric mean (for pharmacokinetic parameters only), arithmetic mean, standard deviation (SD), coefficient of variation, minimum, median and maximum for quantitative variables, and frequency for qualitative variables

These studies have been supported through skin biopsies, revealing a decrease in the number of epidermal fibers, and clinically in subjects presenting the pathology, obtaining higher scores in questionnaires related to neuropathic pain and the presence of alterations in perception thresholds for heat, cold, and pain [12]

Fan H, Liao W, Wu J

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