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Description
By forcing proximity between the target protein and the E3 ligase, PROTAC induces proximity-driven polyubiquitination of the POI, i.e., the proximity forced by the PROTAC results in the transfer of the ubiquitin units from the E3 ligase to the POI 23

Intriguingly, studies exploring GLO system function, specifically GLO I overexpression, yield conflicting results in mitigating atherosclerotic lesions in diabetic models (Figure 3) [82]

[PMC free article] [PubMed] [Google Scholar] 94.Starchl C., Scherkl M., Amrein K

The plasma pharmacokinetic parameters were calculated using baseline-corrected concentrations because quantifiable levels of endogenous NAC were detected at both baseline measurements (evening of Day 1 and pre-dose on Day 1)
