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The peptide achieves these complex neurological stabilizations largely through intricate, bidirectional interactions with the nitric oxide (NO) system, dynamically responding to both NO-system blockade (via L-NAME administration) and NO-system over-stimulation (via L-arginine administration) to restore neurological homeostasis

Probenecid can also be used in combination with allopurinol or febuxostat, if required

Mouse brains were removed into ice-cold Neurobasal A medium (NB) containing B-27 Plus supplement, 5% fetal bovine serum, GlutaMAX-I (1 final concentration), and gentamicin (supplemented NB)

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