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doi: 10.1007/s00281-015-0534-0
For these authors, successful therapy requires both, DNA demethylation and triggering activating histone modifications, to induce complete gene expression of epigenetically silenced genes and depsipeptide fulfills both criteria (Hauptstock et al., 2011)
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These amino acids, which are synthesized via glycolysis and the TCA cycle, may be affected by disruptions in glycolysis
