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2019;10(1, article 3622) doi: 10.1038/s41467-019-11575-1

Most likely, the influence will change with the activity of the steroidogenic processes

[PubMed] [Google Scholar] Kato A, Ueyama J, Abe F, Hotta K, Tsukiyama I, Oshima T, Kondo F, Saito H, and Hasegawa T (2011) Panipenem does not alter the pharmacokinetics of the active metabolite of irinotecan SN-38 and inactive metabolite SN-38 glucuronide (SN-38G) in rats

Hydration : Drink at least 23 liters of water daily
