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Explanations for this excess of men have been attributed to possible protective hormonal factors in women, the increased likelihood of men being exposed to putative risk factors, and the under recognition of older women in some population registries (Wijesekera and Leigh 2009)

In vitro studies have shown that OGP can regulate osteoprogenitor cell proliferation, differentiation, alkaline phosphatase activity, osteocalcin secretion, collagen and matrix mineralization [8587, 92]