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Description
PRDX1 stabilizes NFE2L2 by inhibiting cullin 3 (CUL3)-mediated ubiquitination, thereby promoting transcription of genes involved in GSH synthesis ( GCLC , GCLM ) and cystine import ( SLC7A11 ) 113
Gastroenterology 113 (2), 430433
Unlike many types of cells, pancreatic beta cells express very low levels of lactate dehydrogenase (LDH) [17] and do not regenerate NAD + via lactate formation
Restoring the expression of VRK2 in VRK2-KO cells enhanced the interaction of SLC7A11 and Sec24C (Fig
