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Quercetin activates P53, causes pro-apoptotic Bcl-2-associated X (Bax) and caspase-3, 9 to increase, and triggers a decrease in anti-apoptotic Bcl-2 and survivin

However, individuals with malabsorption disorders (inflammatory bowel disease, celiac disease), severe liver disease, or those taking high-dose chemotherapy should discuss glutathione strategies with their oncologist or gastroenterologist to avoid interactions or supplementation conflicts

J Biol Chem 279:4272642731 Jez JM, Cahoon RE, Chen S (2004) Arabidopsis thaliana glutamate-cysteine ligase: functional properties, kinetic mechanism, and regulation of activity

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