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The nitric oxide modulation extends beyond blood vessel formation to direct anti-inflammatory effects

They made an SLN formulation of coumaric acid and administered it via the nasal route into the brain, which significantly improved the bioavailability and pharmacological activity of coumaric acid[100]

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Of note, as mentioned, BPC 157 may counteract the isoprenaline-induced damage since the very beginning (i.e., 30 min) as it markedly attenuated the early isoprenaline-induced occlusion-like syndrome