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If a patient is suspected to be experiencing OIH, carefully consider appropriately decreasing the dose of the current opioid analgesic, or opioid rotation (safely switching the patient to a different opioid moiety) [seeDOSAGE AND ADMINISTRATION,WARNINGS]
10.1093/mtomcs/mfad014 6 DegorgeM
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Once this is formed, the autophagosome then fuses with lysosomes or endosomes in a process involving several lysosomal proteins such as Lamp1 and Rab7
