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When an external ligand is bound, the GPCR undergoes a conformational shift that releases GDP from the Gsubunit

It binds and unbinds in a constant exchange, so some free copper ions escape and irritate local nerve endings while activating mast cells (immune cells that release histamine and trigger inflammation)

[DOI] [PMC free article] [PubMed] [Google Scholar] 324.Brandon-Warner E., Sugg J.A., Schrum L.W., McKillop I.H

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