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This allows for a sufficient trial length and will allow for enough B12 to make a difference over a sustained period of time
doi: 10.1034/j.1399-3011.1999.00135.x
Critically, AOD-9604 did not produce the metabolic side effects associated with full-length growth hormone, including no insulin resistance or glucose intolerance, no elevation of IGF-1 levels, no fluid retention or joint pain, and no cardiovascular parameter changes
Stomach acid denatures protein structures
