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This oxidative environment subverts immune cell mitochondrial dynamics and redox balance, severely inhibiting the survival, persistence and function of adoptively transferred immune cells [241]

Parisotto EB, Vidal V, Garca-Cerro S, Lantigua S, Wilhelm Filho D, Sanchez-Barcel EJ, Martnez-Cu C, Rueda N (2016) Chronic melatonin administration reduced oxidative damage and cellular senescence in the hippocampus of a mouse model of down syndrome

For positions V12 and F112, many of the tested variants exhibited wild-type-level dehydratase activity (Fig

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